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Singh, Satya Pal
- Ameliorative Effect of Spirulina platensis and Erythrina variegata on Oxidative Stress in Imidacloprid Intoxicated White Leghorn Cockerels
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Affiliations
1 GBPUAT, Pantnagar, IN
2 SKUAST, Jammu, IN
1 GBPUAT, Pantnagar, IN
2 SKUAST, Jammu, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 2 (2017), Pagination: 171-177Abstract
The present experiment was conducted to evaluate the ameliorative efficacy of Erythrina variegata leaf powder (EVLP) and Spirulina platensis (SP, Blue green algae) as feed additives on antioxidant parameters following simultaneous administration of imidacloprid for 60 days in white leghorn cockerels. Forty two white leghorn cockerels weighing 250-275 g of 4-6 months age were selected for this study. Cockerels were divided equally and randomly into six groups T1 to T6 and fed on as control (T1), Spirulina platensis @ 0.2% (T2); imidacloprid @ 50 ppm (T3); Spirulina platensis @ 0.2% plus imidacloprid @ 50 ppm (T4); Erythrina variegata leaf powder (1%) (T5); and Erythrina variegata leaf powder (1%) plus imidacloprid @ 50 ppm (T6) for 60 days. Blood samples were collected at 0, 30 and 60 days interval, tissue samples were collected at the end of the study. A significant (P<0.05) decline in RBC catalase and SOD, and an increase in LPO in RBC, liver, kidney and testes was observed in imidacloprid treated group which returned to normalcy following simultaneous medication with SP and EVLP in T4 and T6 groups after 60 days. Findings of this study indicated that administration of imidacloprid @ 50 ppm in feed for 60 days produced oxidative stress which was ameliorated following simultaneous dietary supplementation of Spirulina platensis and Erythrina variegate @ 0.2% and 1%, respectively. Further, Spirulina platensis was more potent in reversing the oxidative stress induced toxic effects in cockerels.Keywords
Imidacloprid, Erythrina variegata, Spirulina platensis, Oxidative, Cockerels.
References
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- Chronic Toxicity of Indoxacarb and its Amelioration by Rhizome Powder of Hedychium spicatumin WLH Cockerels
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Authors
Affiliations
1 ICAR-KVK, IIVR, Bejwa, Bhadohi, U.P., IN
2 Department of Veterinary Pharmacology & Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, IN
1 ICAR-KVK, IIVR, Bejwa, Bhadohi, U.P., IN
2 Department of Veterinary Pharmacology & Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 2 (2017), Pagination: 203-210Abstract
The objective of the present study was to evaluate the chronic toxicity by determining biochemical parameters after prolong exposure with indoxacarb @ 250 ppm and its amelioration by concurrent administration of rhizome powder of Hydechiumspicatum (HSRP) @ 2000ppm and 4000ppm in feed for 16 weeks in WLH cockerels. The total protein, globulins, albumins and glucose levels in blood serum were significantly (P<0.05) decreased whereas direct bilirubin, indirect bilirubin, BUN, creatinine, ALT, AST, ALP, GGT were significantly (P<0.05) increased in indoxacarb intoxicated cockerels groups indicating hepatotoxic and nephrotoxic effects. Simultaneous administration of HSRP in both 2000ppm and 4000pp min diet produced amelioration in biochemical profile of indoxacarb intoxicated cockerels. Thus, it is concluded that HSRP was effective in restoration of biochemical parameters and revealed hepatoprotective and nephroprotective effects in 16 weeks feeding trial in cockerels.Keywords
Biochemical, Indoxacarb, Hedychium spicatum, WLH Cockerels.References
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- Long Term Exposure with Indoxacarb in WLH Cockerels Produces Reproductive Toxicity and its Amelioration by Rhizome Powder of Shati (Hedychium spicatum)
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Authors
Affiliations
1 Department of Veterinary Pharmacology & Toxicology, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, IN
1 Department of Veterinary Pharmacology & Toxicology, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 3 (2017), Pagination: 269-275Abstract
The toxic effects of indoxacarb on the reproductive organ of cockerel and protective effect of Gandhpalasi (Hedychium spicatum) were evaluated in this study. The dose of indoxacarb was selected on the basis of LD50 in cockerels (250mg/kg). The experimental birds were kept in deep litter system of housing and maintained on grower ration. Birds were sacrificedafter completion of 16 weeks feeding trial. The semen were collected for estimation of mass motility, sperm count and % dead sperm. The antioxidant biomarkers in testis were also estimated. Finally the microscopic and ultrastructure of the testes were seen comparatively in both indoxacarb intoxicated and HSRP treated cockerels. The significant (P<0.05) reduction in sperm count and mass motility in indoxacarb group II and simultaneous treatment with HSRP in group VI and VII showed significant (P<0.05) improvement which was at par with the control. The % dead sperm were increased significantly (P<0.05) in indoxacarb treated group II whereas in HSRP treated group VI and VII showed significant decline in dose dependent manner. The antioxidant biomarker were significantly (P<0.05) changes by indoxacarb intoxication but treatment HSRP produced significant (P<0.05) amelioration. At the time of microscopic and ultrastructure examination of testes showed changes in indoxacarb treated group II and in HSRP treated group VI and VII showed mild to moderate changes. It is concluded from the present study that the HSRP produced protective effect in indoxacarb induced reproductive toxicity and its amelioration by HSRP treatment.Keywords
Indoxacarb, Cockerel, Gandhpalaasi (Hedychium spicatum), Reproductive Toxicity.References
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